Figure 2.

Rho GTPase signaling in chondrocyte development and maturation. Rac1/Cdc42 and RhoA/ROCK signaling pathways are all required for chondrogenesis, and have antagonistic effects on chondrocyte terminal differentiation, which is probably mediated by interaction with Sox9 and Runx2.

Zhu et al. Arthritis Research & Therapy 2013 15:217   doi:10.1186/ar4240
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