Table 2

IL-10-producing B cells, IDO-expressing dendritic cells and forkhead box protein 3-expressing regulatory T peripheral cells

Variable

Control

(n = 25)

All

pSS patients

(n = 50)

Clinically active

pSS patients

(n = 17)

Clinically inactive

pSS patients

(n = 33)

Serologically active

pSS patients

(n = 29)

Serologically inactive

pSS patients

(n = 18)

Clinically and serologically active pSS patients

(n = 12)

Clinically active and serologically inactive

pSS patients

(n = 4)

Clinically inactive and serologically active pSS patients

(n = 17)

Clinically and

serologically inactive

pSS patients

(n = 14)


CD19+ B cells from PBMCs (%)

Mean ± SEM

Median

Range

10.7 ± 0.7

10.5

5.2 to 19.3

11.0 ± 1.0

10.5

0.4 to 30.0

11.0 ± 1.6

10.7

1.6 to 27.3

11.0 ± 1.2

10.1

0.4 to 30.0

11.2 ± 1.3

9.4

0.4 to 30.0

13.0 ± 1.6

11.9

1.0 to 27.3

9.8 ± 2.1

10.0

1.6 to 27.3

15.6 ± 1.2

14.7

14.0 to 19.0

10.5 ± 1.7

8.4

0.4 to 30.0

12.2 ± 2.0

10.5

1.0 to 27.3

IL-10--producing B cells (%)

CD19+/CD38hi

Mean ± SEM

Median

Range

1.6 ± 0.2

1.4

0.8 to 4.5

3.5 ± 0.3

2.9

0.3 to 9.0

3.8 ± 0.7

2.9

0.3 to 9.0

3.4 ± 0.3

2.9

1.2 to 8.8

3.8 ± 0.5

2.9

0.3 to 9.0

3.0 ± 0.3

2.8

1.2 to 5.8

4.0 ± 0.9

3.4

0.3 to 9.0

2.3 ± 0.5

2.1

1.3 to 3.6

3.6 ± 0.5

2.8

1.4 to 8.8

3.3 ± 0.3

3.0

1.2 to 5.8

CD19+/CD38hi/IL-10+

Mean ± SEM

Median

Range

0.13 ± 0.02

0.10

0.03 to 0.40

0.16 ± 0.02

0.12

0.03 to 0.91

0.18 ± 0.05

0.14

0.03 to 0.91

0.15 ± 0.02

0.11

0.03 to 0.43

0.17 ± 0.03

0.12

0.03 to 0.91

0.14 ± 0.03

0.08

0.03 to 0.35

0.21 ± 0.07

0.25

0.04 to 0.91

0.09 ± 0.05

0.07

0.03 to 0.21

0.14 ± 0.03

0.10

0.03 to 0.43

0.16 ± 0.03

0.13

0.03 to 0.35

CD19+/CD38hi/IgA+/IL-10+

Mean ± SEM

Median

Range

65.8 ± 1.5

66.4

51.3 to 78.6

75.7 ± 1.9

77.3e

36.4 to 94.6

75.2 ± 3.6

74.6

45.8 to 94.6

76.3 ± 2.6

80.4e

36.4 to 93.8

75.3 ± 2.6

78.1e

36.4 to 94.6

75.3 ± 3.7

75.7e

43.3 to 93.8

72.9 ± 4.5

74.4

45.8 to 94.6

77.7 ± 3.4

75.7

73.0 to 84.4

76.9 ± 3.2

80.0e

36.4 to 89.8

74.5 ± 5.0

78.8

43.3 to 93.8

CD19+/CD38hi/IgG+/IL-10+

Mean ± SEM

Median

Range

55.3 ± 2.8

60.8

26.7 to 79.6

42.8 ± 2.0

41.7e

22.2 to 74.2

38.6 ± 3.7

32.9e

22.2 to 65.2

48.1 ± 2.0

48.6ae

31.4 to 74.2

45.3 ± 2.5

41.7e

23.2 to 74.2

45.2 ± 3.2

46.0

22.2 to 59.3

39.3 ± 4.2

32.9e

23.2 to 65.2

41.2 ± 10.7

42.1

22.2 to 59.3

49.2 ± 2.9

49.5

31.4 to 74.2

46.6 ± 3.0

46.2

33.3 to 57.8

CD19+/CD38hi/IgM+/IL-10+

Mean ± SEM

Median

Range

21.7 ± 1.3

21.1

10.7 to 35.0

22.8 ± 1.5

20.2

3.0 to 54.0

20.2 ± 2.4

15.8

10.0 to 38.7

25.1 ± 2.2

22.7

3.0 to 54.0

22.8 ± 2.1

21.1

3.0 to 52.2

25.4 ± 3.2

23.1

12.1 to 54.0

21.7 ± 3.1

22.6

10.2 to 38.7

16.4 ± 1.7

15.8

13.8 to 19.5

23.5 ± 2.8

20.2

3.0 to 52.2

28.2 ± 3.8

28.2

12.1 to 54.0

CD19+/CD38hi/CD24hi

Mean ± SEM

Median

Range

0.7 ± 0.1

0.5

0.2 to 2.9

0.6 ± 0.1

0.5

0.1 to 1.6

1.7 ± 0.4

1.1

0.3 to 4.7

2.2 ± 0.3

2.0

0.4 to 7.7

2.2 ± 0.3

1.7

0.3 to 8.8

1.8 ± 0.2

1.7

0.4 to 3.7

1.9 ± 0.5

1.0

0.3 to 4.7

0.8 ± 0.2

0.8

0.4 to 1.3

2.4 ± 0.4

2.0

0.5 to 7.7

2.1 ± 0.3

2.2

0.5 to 3.7

CD19+/CD38hi/CD24hi/IL-10+

Mean ± SEM

Median

Range

0.20 ± 0.02

0.19

0.06 to 0.44

0.55 ± 0.05

0.46 e

0.12 to 1.59

0.38 ± 0.05

0.37

0.12 to 0.87

0.63 ± 0.06

0.56e

0.13 to 1.59

0.57 ± 0.07*

0.47e

0.12 to 1.59

0.53 ± 0.07

0.46e

0.15 to 1.07

0.40 ± 0.06

0.40

0.12 to 0.87

0.32 ± 0.06

0.32

0.18 to 0.47

0.69 ± 0.09

0.65e

0.13 to 1.59

0.59 ± 0.08

0.52e

0.15 to 1.07

CD19+/CD38hi/CD24hi/CD5+/IL-10+

Mean ± SEM

Median

Range

17.7 ± 1.3

15.5

8.6 to 32.4

20.2 ± 1.4

20.0

2.8 to 45.2

11.4 ± 1.4

10.9e

2.8 to 22.8

24.8 ± 1.4

23.7a e

8.0 to 45.2

18.8 ± 1.7

18.8

2.8 to 38.7

22.9 ± 2.5

23.5

7.1 to 45.2

11.9 ± 1.8

11.8 e

2.8 to 22.8

11.0 ± 2.3

10.1

7.1 to 16.6

23.1 ± 2.0

22.0

8.0 to 38.7

27.1 ± 2.2

24.2e

16.2 to 45.2

CD19+/CD38hi/CD24hi/CD10+/IL-10+

Mean ± SEM

Median

Range

15.8 ± 1.3

16.7

3.3 to 27.0

22.5 ± 1.6

22.9e

4.4 to 42.9

16.9 ± 2.8

13.8

4.4 to 39.7

25.5 ± 1.7

25.6ae

6.6 to 42.9

19.5 ± 2.0

20.0

4.4 to 39.7

27.5 ± 2.2

26.3be

10.3 to 42.9

16.1 ± 3.9

10.7

4.4 to 39.7

19.6 ± 3.9

19.8

10.3 to 28.6

21.9 ± 2.1

22.9e

6.6 to 33.3

30.1 ± 2.1

29.8de

18.2 to 42.9

CD19+/CD38hi/CD24hi/CD20+/IL-10+

Mean ± SEM

Median

Range

20.3 ± 1.6

17.5

11.1 to 37.2

29.4 ± 2.1

27.9e

10.2 to 66.7

23.8 ± 3.2

16.2

10.2 to 46.2

32.5 ± 2.6

30.9ae

12.6 to 66.7

27.9 ± 2.5

23.8

12.5 to 54.8

28.5 ± 3.6

26.6

10.2 to 66.7

23.8 ± 3.5

16.5

12.5 to 45.5

18.4 ± 7.2

11.6

10.2 to 40.0

30.7 ± 3.3

33.0e

12.6 to 54.8

31.2 ± 3.8

27.3e

16.2 to 66.7

CD19+/CD38hi/CD24hi/CD27+/IL-10+

Mean ± SEM

Median

Range

35.4 ± 2.1

34.0

21.5 to 54.5

38.8 ± 1.8

41.0

11.3 to 68.5

37.0 ± 3.0

39.6

11.5 to 61.8

39.7 ± 2.3

41.0

11.3 to 68.5

40.1 ± 2.4

41.5

11.5 to 68.5

36.9 ± 2.7

37.9

11.3 to 52.5

37.5 ± 3.7

38.1

11.5--61.8

41.5 ± 1.8

43.0

37.9 to 43.6

42.0 ± 3.2

42.4

18.4 to 68.5

35.6 ± 3.2

35.0

11.3 to 52.5

CD19+/CD38hi/CD24hi/CD27--/IL-10+

Mean ± SEM

Median

Range

11.3 ± 1.8

7.8

0.0 to 32.6

23.9 ± 1.8

20.7e

5.5 to 52.7

25.8 ± 3.8

22.4e

5.5 to 52.7

23.0 ± 1.9

20.2e

7.4 to 49.5

26.1 ± 2.5

21.7e

5.5 to 52.7

20.5 ± 2.5

17.9e

7.4 to 41.7

27.8 ± 4.9

28.2e

5.5 to 52.7

21.5 ± 0.94

21.7

19.8 to 23.0

25.0 ± 2.6

20.7e

9.8 to 49.5

20.7 ± 2.9

14.6e

7.4 to 41.7

CD19+/CD38hi/CD24hi/CXCR4+/IL-10+

Mean ± SEM

Median

Range

28.3 ± 1.3

27.3

19.6 to 43.2

26.6 ± 1.5

27.0

9.6 to 46.1

23.0 ± 3.2

15.1

9.6 to 46.1

28.6 ± 1.4

28.9

16.0 to 44.4

25.4 ± 1.9

24.5

12.5 to 46.1

28.0 ± 2.6

28.1

9.6 to 44.4

21.8 ± 3.6

15.0

12.5 to 46.1

28.0 ± 9.1

29.0

9.6 to 44.4

28.1 ± 1.8

28.5

16.0 to 43.2

28.1 ± 2.1

28.5

17.2 to 44.4

CD19+/CD38hi/CD24hi/CXCR7+/IL-10+

Mean ± SEM

Median

Range

20.6 ± 1.3

18.7

12.3 to 33.1

25.9 ± 2.3

22.5

5.6 to 85.7

18.2 ± 2.5

17.3

5.6 to 34.62

29.5 ± 2.9

26.1ae

7.3 to 85.7

24.3 ± 3.1

20.3

5.6 to 85.7

27.2 ± 3.0

27.2

10.8 to 50.0

17.4 ± 2.6

17.4

5.6 to 33.6

20.9 ± 7.1

17.2

10.8 to 34.6

28.8 ± 4.5

23.0

7.3 to 85.7

27.9 ± 3.2

27.2

17.1 to 50.0

pDC IDO+ (%)

CCR6+

Mean ± SEM

Median

Range

15.3 ± 0.9

16.5

8.7 to 21.8

16.7 ± 0.8

15.6

8.6 to 31.1

15.2 ± 1.1

15.4

8.6 to 24.7

17.5 ± 1.1

16.1

9.2 to 31.1

16.1 ± 1.0

15.5

8.6 to 28.7

18.4 ± 1.6

17.8

9.5 to 31.1

14.4 ± 1.3

14.3

8.6 to 24.6

17.3 ± 2.8

19.0

9.5 to 21.1

17.2 ± 1.3

16.1

9.2 to 28.7

19.1 ± 2.3

16.2

10.3 to 31.1

CD123+/CCR6+

Mean ± SEM

Median

Range

0.40 ± 0.06

0.35

0.12 to 0.98

0.35 ± 0.07

0.2

0.03 to 2.89

0.29 ± 0.06

0.2

0.07 to 0.82

0.38 ± 0.11

0.19

0.03 to 2.89

0.29 ± 0.34

0.2

0.03 to 1.84

0.42 ± 0.18

0.2

0.07 to 2.9

0.3 ± 0.06

0.21

0.08 to 0.72

0.14 ± 0.03

0.15

0.07 to 0.2

0.29 ± 0.10

0.15

0.03 to 1.84

0.46 ± 0.27

0.20

0.13 to 2.89

CD123+/CCR6+/IDO+

Mean ± SEM

Median

Range

16.6 ± 1.0

16.7

10.2 to 29.6

27.4 ± 1.8

26.7e

7.4 to 57.2

30.8 ± 3.5

28.7e

14.2 to 57.2

25.5 ± 2.0

23.9e

7.4 to 49.4

28.0 ± 2.3

27.7e

7.4 to 57.2

28.4 ± 3.2

28.2e

12.1 to 49.4

31.4 ± 4.5

28.9e

14.2 to 57.2

31.9 ± 6.0

32.8 c e

18.0 to 44.0

25.5 ± 2.4

27.4e

7.4 to 43.0

27.2 ± 3.9

27.1e

12.1 to 49.4

Foxp3--expressing T cells (%)

CD4+

Mean ± SEM

Median

Range

28.4 ± 1.3

26.6

18.7 to 43.0

22.7 ± 1.4

22.7

7.1 to 45.7

20.6 ± 2.1

17.3

10.8 to 45.7

23.5 ± 1.8

25.2

7.1 to 39.8

22.1 ± 1.8

21.4

7.1 to 45.7

23.3 ± 2.5

26.1

8.6 to 39.8

21.1 ± 2.7

18.2

12.5 to 45.7

18.0 ± 4.1

15.7

10.8 to 29.9

22.8 ± 2.4

23.0

7.1 to 38.0

25.4 ± 3.3

26.9

8.6 to 39.8

CD4+/CD25hi

Mean ± SEM

Median

Range

0.78 ± 0.14

0.54

0.17 to 2.69

0.36 ± 0.06

0.26e

0.10 to 2.93

0.27 ± 0.04

0.20e

0.12 to 0.64

0.40 ± 0.09

0.27

0.10 to 2.93

0.27 ± 0.03

0.25e

0.10 to 0.80

0.52 ± 0.17

0.28

0.12 to 2.93

0.28 ± 0.04

0.23

0.12 to 0.64

0.28 ± 0.09

0.28

0.12 to 0.44

0.27 ± 0.04

0.25e

0.10 to 0.80

0.53 ± 0.24

0.28

0.12 to 2.93

CD4+/CD25hi/Foxp3+

Mean ± SEM

Median

Range

5.7 ± 0.3

5.8

3.3 to 9.0

6.4 ± 0.4

6.5

1.4 to 11.2

6.2 ± 0.6

5.9

2.2 to 11.2

6.5 ± 0.4

6.6

1.4 to 10.9

6.7 ± 0.5

6.9

2.0 to 11.6

6.1 ± 0.6

6.1

1.4 to 10.9

6.6 ± 0.8

6.4

2.2 to 11.2

6.2 ± 1.2

5.8

4.0 to 9.2

6.8 ± 0.6

6.9

2.0 to 10.4

6.0 ± 0.7

6.1

1.4 to 10.9

CD8+

Mean ± SEM

Median

Range

10.5 ± 0.8

10.6

3.5 to 16.7

12.2 ± 1.2

10.1

3.2 to 38.4

12.6 ± 2.5

8.7

3.2 to 38.4

11.8 ± 1.3

10.7

3.3 to 27.0

13.0 ± 1.8

9.7

3.2 to 38.4

10.9 ± 1.5

10.5

3.3 to 27.0

14.4 ± 3.5

10.1

3.2 to 38.4

8.2 ± 1.9

6.6

5.8 to 13.9

12.1 ± 2.0

9.7

3.5 to 25.6

12.3 ± 2.1

12.0

3.3 to 27.0

CD8+/CD28--

Mean ± SEM

Median

Range

3.7 ± 0.3

3.4

1.1 to 8.2

5.1 ± 0.6

3.6

0.8 to 17.4

5.4 ± 1.2

3.4

1.0 to 17.4

4.9 ± 0.6

3.7

0.8 to 13.6

5.8 ± 0.9

4.0

0.8 to 17.4

4.1 ± 0.6

3.6

1.4 to 9.3

6.1 ± 1.6

3.7

1.0 to 17.4

4.0 ± 1.3

3.5

1.4 to 7.4

5.6 ± 1.0

4.9

0.8 to 13.6

4.1 ± 0.7

3.6

1.6 to 9.3

CD8+/CD28--/Foxp3+

Mean ± SEM

Median

Range

5.6 ± 0.3

5.6

2.8 to 8.8

3.9 ± 0.3

3.7 e

1.1 to 8.9

4.2 ± 0.6

4.0

1.2 to 8.9

3.8 ± 0.3

3.6 e

1.1 to 7.3

3.9 ± 0.4

3.5 e

1.1 to 8.9

4.2 ± 0.5

4.4

1.8 to 8.5

4.0 ± 0.8

3.7

1.3 to 8.9

5.3 ± 1.2

5.1

2.6 to 8.5

3.8 ± 0.5

3.5 e

1.1 to 7.3

3.9 ± 0.5

3.9 e

1.8 to 6.8


Control, control group of healthy individuals. aP < 0.05: patients with clinically active versus clinically inactive primary Sjögren's syndrome (pSS); bP < 0.05: patients with serologically active versus serologically inactive pSS; cP < 0.05: patients with clinically and serologically active versus clinically active but serologically inactive pSS; dP < 0.05: patients with clinically inactive but serologically active versus clinically and serologically inactive pSS. IDO, indoleamine 2,3-dioxygenase; PBMCs, peripheral blood mononuclear cells; SEM, standard error of the mean; pDC, plasmacytoid dendritic cells.

Furuzawa-Carballeda et al. Arthritis Research & Therapy 2013 15:R68   doi:10.1186/ar4245

Open Data