Macrophage migration inhibitory factor (MIF) gene expression and DNA methylation status in MIF gene promoter in peripheral blood mononuclear cells (PBMC). (A) Real-time reverse transcriptase (RT)-PCR quantification of MIF mRNA relative level in the adult-onset Still's disease (AOSD) and healthy control groups. (B) Methylation status of 34 CpG sites of the proximal human MIF promoter in PBMC isolated from AOSD patients and healthy donors. Black circles represents methylated cytosines and white circles represents unmethylated sites.
Wang et al. Arthritis Research & Therapy 2013 15:R65 doi:10.1186/ar4239