Table 1

Characteristics of patients with Muckle-Wells syndrome (MWS) treated with interleukin-1-blocking therapy

Anakinra

cohort

n = 12

Canakinumab cohort

n = 14


Demographics


Male/female patients

3:9

5:9


% females

75

64


Median age at MWS diagnosis in years (range)

19.0

(3.0 to 65.5)

27.0

(3.0 to 72)


Median age at anti IL-1 therapy in years (range)

21.0

(3.0 to 66.5)

29.0

(4.0 to 74.5)


NLRP3 mutation


Mutation subtypes:

   E311K No (%)

   T348M No (%)

   V198M No (%)

7/12 (58%)

3/12 (25%)

2/12 (17%)

10/14 (71%)

2/14 (14%)

2/14 (14%)


Follow-up


Median follow-up

in months (range)

52 (23 to 115)

50 (23 to 110)


Kuemmerle-Deschner et al. Arthritis Research & Therapy 2013 15:R64   doi:10.1186/ar4237

Open Data