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Open Access Highly Accessed Research article

A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose

David Pretzel14*, Stefanie Linss1, Hannes Ahrem26, Michaela Endres3, Christian Kaps3, Dieter Klemm5 and Raimund W Kinne1

Author Affiliations

1 Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Friedrich Schiller University Jena, Waldkrankenhaus "Rudolf-Elle" GmbH, Klosterlausnitzer Str. 81, D-07607 Eisenberg, Germany

2 Jenpolymer Materials Ltd. & Co. KG, Technologie- und Innovationspark Jena - TIP, Wildenbruchstraße 15, D-07745 Jena, Germany

3 TransTissueTechnologies GmbH, Charitéplatz 1/Virchowweg 11, D-10117 Berlin, Germany

4 Institute of Macromolecular and Organic Chemistry, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany

5 Transfer Group Polymet e.V., Wildenbruchstr. 15, D-07745 Jena, Germany

6 Institute of Pharmacy, Department of Pharmaceutical Technology, Friedrich Schiller University Jena, Otto-Schott-Straße 41, D-07745 Jena, Germany

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Arthritis Research & Therapy 2013, 15:R59  doi:10.1186/ar4231

Published: 14 May 2013

Additional files

Additional file 1:

Scanning electron micrographs of BNC (A) and bovine cartilage (B). Note the apparent ultrastructural similarity of the three-dimensional BNC network and the cartilaginous collagen fibers. Magnification: 5,000x.

Format: DOCX Size: 863KB Download file

Open Data

Additional file 2:

HE-stained vertical and cross sections of a cartilage cylinder containing a BNC insert. Note the tight bonding of the BNC material to the surrounding cartilage edges. Magnification: 40 x.

Format: DOCX Size: 938KB Download file

Open Data