Table 3

Vascular measures of atherosclerosis in juvenile idiopathic arthritis

Argyropoulou and colleagues [85]

Vlahos and colleagues [87]

Breda and colleagues [86]


JIA (n)

31

30

38

Oligoarticular subtype

18

15

-

Polyarticular subtype

6

8

-

Systemic subtype

7

7

-

Age (years)

13.6 (3.4 to 26.2)

12.0 ± 3.0

7.1 ± 2.4

Disease duration (years)

9.1 ± 5.4

6.6 ± 3.8

22.9

CIMT (mm)

Not reported

0.46 ± 0.03 (patients) vs. 0.45 ± 0.03 (controls)

0.38 ± 0.05 (patients)a vs. 0.31 ± 0.05 (controls)

FMD (%)

Not reported

7.10 ± 2.23 (patients)b vs. 9.93 ± 3.90 (controls)

Not reported

PWV (m/s)

3.68 ± 1.59 (patients)a vs. 1.38 ± 0.54 (controls)

5.5 ± 0.9 (patients) vs. 5.7 ± 1.0 (controls)

Not reported

Inflammatory markers

Not reported

Increased

Increased

Cytokines/endothelial activation

Not reported

Increased

Increased


Values are presented as mean ± standard deviation or median (range), unless otherwise specified. CIMT, carotid intima-media thickness; FMD, flow-mediated dilatation; JIA, juvenile idiopathic arthritis; PWV, pulse wave velocity. aDifference from controls is statistically significant (P <0.01). bDifference from controls is statistically significant (P = 0.001).

Barsalou et al. Arthritis Research & Therapy 2013 15:212   doi:10.1186/ar4212