Table 2

Serial carotid intima-media thickness measurements in pediatric-onset systemic lupus erythematosus

Source

Number (% female)

Age (years)

Disease duration (years)

Frequency of CIMT assessment

CIMT progression (mm/year)


Huang and colleagues [20]

76 (90%)

15.0 ± 3.5

2.7 ± 2.5

Baseline and every 6 monthsa

0.0016 ± 0.0016b

Schanberg and colleagues [26]

108 (82%)c

15.8 ± 2.5

2.5 ± 2.3

Baseline, 6, 12, 24 and 36 months

0.0024 (0.0007, 0.0040)d

113 (84%)e

15.7 ± 2.8

2.7 ± 2.4

0.0010 (-0.0006, 0.0026)d


Values presented as mean ± standard deviation, unless otherwise specified. CIMT, carotid intima-media thickness. aMean number of CIMT assessments performed: 4.6 ± 1.6. bMean ± standard error; CIMT adjusted for age at diagnosis. cSubjects were in the placebo arm of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial. dCIMT presented as mean (95% confidence interval). eSubjects were in the atorvastatin arm of the APPLE trial.

Barsalou et al. Arthritis Research & Therapy 2013 15:212   doi:10.1186/ar4212