Table 3

Association between nailfold videocapillaroscopy patterns and disease characteristics of patients with systemic sclerosis included in the discovery cohort

NVC pattern

P value

Multiple linear regression

(r)

P value


Early/active

(n = 36)

Late

(n = 24)


Age, median (range)

58

53

0.2

Females, n (%)

27 (75)

19

0.9

Disease duration, median (range)

9.91

7.20

0.2

Diffuse cutaneous subset, n (%)

13 (36)

11 (46)

0.9

Modified Rodnan skin score > 14, n (%)

6 (17)

13 (54)

0.005*

0.42

0.0008

History of digital ulcers, n (%)

13 (36)

16 (67)

0.03*

0.25

0.03

Pulmonary fibrosis, n (%)

15 (42)

13 (54)

0.5

Pulmonary arterial hypertension on RHC, n (%)

2 (6)

2 (8)

0.9

Positive antitopoisomerase antibodies, n (%)

12 (33)

16 (67)

0.02*

Positive anticentromere antibodies, n (%)

9 (25)

3 (13)

0.4

FVC < 75, n (%)

5 (14)

8 (33)

0.1*

0.29

0.01

DLCO/VA < 75%, n (%)

9 (25)

14 (58)

0.02*

Treatment with angiotensin-converting enzyme inhibitors, n (%)

8 (22)

11 (46)

0.09*

Treatment with endothelin-receptor antagonists and/or PDE5 inhibitors, n (%)

4 (11)

8 (33)

0.08*


DLCO/AV, diffusing capacity for carbon monoxide/alveolar volume; FVC, forced vital capacity; NVC, nailfold videocapillaroscopy; PDE5, phosphodiesterase type 5; RHC, right heart catheterization.

    * Variables included in multiple regression analysis

Avouac et al. Arthritis Research & Therapy 2013 15:R55   doi:10.1186/ar4217

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