Table 4

Significant results from gene-environment interactions of TGFβ1 SNPs and BMI in OA

TGFβ1 SNP

OA phenotyp

Interaction

Univariate

Adjusted‡ OR


ORINT

(95% CI)

P-Value (LRT)

ORINT

(95% CI)

P-Value (LRT)


rs11466321

Knee OA

Multiplicative

0.96

(0.49, 1.91)

0.911

1.08

(0.50, 2.31)

0.851

RERI

4.25

(2.46, 6.05)

0.67

(-0.92, 2.26)

AP

0.75

(0.59, 0.90)

0.14

(-0.16, 0.44)

Synergy Index

10.46

(1.42, 77.30)

1.21

(0.77, 1.89)

rs2278422§

Knee OA

Multiplicative

0.47

(0.27, 0.81)

0.005

0.47

(0.26, 0.86)

0.013

RERI

-3.09

(-5.37, -0.81)

-2.66

(-4.96, -0.36)

AP

-0.61

(-0.95, -0.27)

-0.56

(-0.94, -0.17)

Synergy Index

0.57

(0.45, 0.72)

0.59

(0.44, 0.78)

rs1800468¶

Hip OA

Multiplicative

2.78

(1.46, 5.30)

0.001

2.27

(1.15, 4.48)

0.015

RERI

1.06

(0.38, 1.75)

0.93

(0.19, 1.67)

AP

0.46

(0.24, 0.68)

0.42

(0.16, 0.68)

Synergy Index

5.32

(0.72, 39.11)

4.33

(0.59, 31.96)


‡Adjusted for age, gender, nodal OA, joint injury, occupational risk factors and bone mineral density (z-score). §Statistically significant with RERI <0, AP <0, and synergy index (SI) <1 indicating an antagonistic interaction. Statistically significant with RERI >0, AP >0, and SI >1, indicating a synergetic interaction. TGFβ1, transforming growth factor β1; SNP, single nucleotide polymorphism; BMI, body mass index; OA, osteoarthritis; OR, odds ratio; ORINT, odds ratio for interaction; LRT, likelihood ratio test; RERI, relative excess risk due to interaction; AP, attributable proportion.

Muthuri et al. Arthritis Research & Therapy 2013 15:R52   doi:10.1186/ar4214

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