Table 3

Risk estimates for the association of TGFβ1 SNPs with hip OA by being overweight (BMI >25 kg/m2)

SNP

Genotype

Overweight

Hip OA

Controls

Univariate

Adjusted†

Adjusted‡


N

N

OR

(95% CI)

P-value

ORs

(95% CI)

P-value

ORs

(95% CI)

P-value


rs11466321

11

-

162

273

1.00

1.00

1.00

12/22

-

30

41

1.23

(0.74, 2.05)

0.420

1.22

(0.72, 2.06)

0.466

1.18

(0.68, 2.05)

0.552

11

+

683

548

2.10

(1.68, 2.63)

<0.001

2.25

(1.78, 2.84)

<0.001

1.97

(1.54, 2.53)

<0.001

12/22

+

125

98

2.17

(1.56, 3.02)

<0.001

2.22

(1.58, 3.12)

<0.001

1.92

(1.34, 2.74)

<0.001

rs8179181

11

-

17

15

1.00

1.00

1.00

12/22

-

197

261

0.67

(0.32, 1.37)

0.268

0.57

(0.27, 1.21)

0.143

0.72

(0.33, 1.56)

0.404

11

+

43

49

0.77

(0.35, 1.73)

0.534

0.75

(0.32, 1.75)

0.505

0.79

(0.33, 1.90)

0.602

12/22

+

728

617

1.04

(0.52, 2.11)

0.907

0.94

(0.45, 1.97)

0.871

1.03

(0.48, 2.21)

0.944

rs8105161

11

-

9

13

1.00

1.00

1.00

12/22

-

182

299

0.88

(0.37, 2.10)

0.772

0.95

(0.39, 2.31)

0.906

0.94

(0.38, 2.33)

0.890

11

+

19

18

1.52

(0.52, 4.43)

0.438

1.78

(0.59, 5.34)

0.304

1.75

(0.57, 5.41)

0.329

12/22

+

790

623

1.83

(0.78, 4.32)

0.165

2.09

(0.87, 5.03)

0.098

1.82

(0.74, 4.45)

0.189

rs2278422

11

-

66

113

1.00

1.00

1.00

12/22

-

126

197

1.10

(0.75, 1.60)

0.637

1.08

(0.73, 1.60)

0.703

1.07

(0.71, 1.60)

0.751

11

+

260

182

2.46

(1.72, 3.52)

<0.001

2.55

(1.76, 3.70)

<0.001

2.26

(1.53, 3.33)

<0.001

12/22

+

542

462

2.01

(1.45, 2.79)

<0.001

2.14

(1.52, 3.02)

<0.001

1.85

(1.29, 2.65)

0.001

rs2241718

11

-

9

13

1.00

1.00

1.00

12/22

-

182

293

0.90

(0.38, 2.14)

0.807

0.95

(0.39, 2.31)

0.905

0.95

(0.38, 2.35)

0.908

11

+

23

25

1.33

(0.48, 3.69)

0.585

1.60

(0.56, 4.59)

0.377

1.59

(0.54, 4.67)

0.395

12/22

+

766

607

1.83

(0.78, 4.30)

0.168

2.04

(0.85, 4.90)

0.112

1.78

(0.73, 4.36)

0.205

rs1800468

11

-

174

258

1.00

1.00

1.00

12/22

-

17

54

0.47

(0.26, 0.83)

0.010

0.52

(0.28, 0.93)

0.029

0.57

(0.31, 1.05)

0.071

11

+

661

551

1.78

(1.43, 2.23)

<0.001

1.92

(1.52, 2.42)

<0.001

1.71

(1.33, 2.18)

<0.001

12/22

+

140

90

2.31

(1.66, 3.20)

<0.001

2.47

(1.75, 3.47)

<0.001

2.21

(1.55, 3.15)

<0.001

rs1800469

11

-

13

27

1.00

1.00

1.00

12/22

-

178

281

1.32

(0.66, 2.62)

0.434

1.39

(0.68, 2.84)

0.362

1.37

(0.66, 2.85)

0.396

11

+

65

59

2.29

(1.08, 4.84)

0.030

2.46

(1.13, 5.35)

0.024

2.09

(0.94, 4.65)

0.072

12/22

+

727

567

2.67

(1.36, 5.22)

0.004

3.00

(1.50, 6.02)

0.002

2.61

(1.28, 5.35)

0.009

rs1982073

11

-

74

127

1.00

1.00

1.00

12/22

-

112

180

1.07

(0.74, 1.55)

0.729

1.11

(0.76, 1.63)

0.594

1.22

(0.82, 1.83)

0.323

11

+

294

257

1.96

(1.41, 2.74)

<0.001

2.22

(1.57, 3.14)

<0.001

2.06

(1.44, 2.95)

<0.001

12/22

+

498

374

2.29

(1.67, 3.14)

<0.001

2.45

(1.76, 3.40)

<0.001

2.27

(1.61, 3.20)

<0.001


For Overweight, -indicates not overweight, + indicates overweight; †adjusted for age and gender; ‡adjusted for age, gender, nodal OA, hip injury, occupational risk factors and bone mineral density (Z score); TGFβ1, transforming growth factor β1; SNP, single nucleotide polymorphism; OA, osteoarthritis; OR, odds ratio.

Muthuri et al. Arthritis Research & Therapy 2013 15:R52   doi:10.1186/ar4214

Open Data