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Open Access Research article

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis

Stella G Muthuri1, Sally Doherty2, Weiya Zhang2, Rose A Maciewicz3, Kenneth R Muir4 and Michael Doherty2*

Author Affiliations

1 Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK

2 Academic Rheumatology, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK

3 Respiratory & Inflammation, AstraZeneca, Charnwood R&D, Loughborough, Leicestershire, LE11 5RH, UK

4 Heath Services Research Institute, Warwick Medical School and Warwick University, Coventry CV4 7AL, UK

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Arthritis Research & Therapy 2013, 15:R52  doi:10.1186/ar4214

Published: 18 April 2013

Additional files

Additional file 1:

Additive and multiplicative gene-environment interactions in knee and hip osteoarthritis. This file contains two tables with results on additive and multiplicative gene-environment interactions among transforming growth factor (TGF)β1 single nucleotide polymorphisms (SNPs), body mass index (BMI) and osteoarthritis (OA). Table S1: Gene-environment interactions among TGFβ1 SNPs, BMI and knee OA. Table S2: Gene-environment interactions among TGFβ1 SNPs, BMI and hip OA.

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