Effect of muraglitazar on carrageenan-induced paw oedema in the mouse. Muraglitazar, inducible nitric oxide synthase (iNOS) inhibitor L-NIL, dexamethasone or vehicle (2.0% CMC) were given to animals per os 1 hour prior to carrageenan injection (1%). Paw oedema was measured before and one, four and six hours after carrageenan injection by micrometer. Oedema is expressed as increase in paw thickness at indicated time points compared to thickness before carrageenan. Values are mean + SEM (n = 6). *P <0.05 and **P <0.01 as compared to mice treated with carrageenan alone.
Paukkeri et al. Arthritis Research & Therapy 2013 15:R51 doi:10.1186/ar4211