Table 2

Clinical sensitivity and specificity of anti-Th/To antibodies measured by QUANTA Flash Rpp25 vs a commercial line immunoassay for systemic sclerosis (SSc)

Villalta et al.

Bonroy et al.

Present study


Method

EUROLINE SSc Profile

EUROLINE SSc Profile

QUANTA Flash Rpp25 (CLIA)

Sensitivity1

7/210 (3.3; 1.3, 6.7)

3/145 (2.1; 0.4, 5.9)

2/70 (2.9; 0.3, 9.9)

Specificity2

148/150 (98.7; 95.2, 99.9)

271/277 (97.8; 95.3, 99.2)

365/367 (99.5; 98.0, 99.9)

LR+

2.5

0.96

5.24

LR-

0.98

1.0

0.98


1Values are presented as number of positives/number of SSc samples tested (percent positive; 95% CI). 2Values are presented as number of negatives/number of non-SSc samples tested (percent negative; 95%CI). LR+, positive likelihood ratio; LR-, negative likelihood ratio; CLIA, chemiluminescent assay.

Mahler et al. Arthritis Research & Therapy 2013 15:R50   doi:10.1186/ar4210

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