Restoration of chronic graft vs host disease (Cgvhd)-induced autoantibody (autoAb) by human granulocyte-colony stimulation factor (huG-CSF) correlates with CD4+ T cell activation, as well as DC and GR-1+ cell expansion. (A) huG-CSF 12 × 2 treatment increased CD69 expression, reduced the percentage of naïve CD62L+ CD44- CD4+ T cells and expanded the percentage of the CD62L- CD44+ effector memory CD4+ T cells in B6.Sle2c2 mice compared to dextrose-treated controls. (B) huG-CSF 12 × 2 treatment increased the percentage of CD11b+ CD11c+, GR1hi CD11b+ and GR1lo CD11b+ cells in B6.Sle2c2 mice compared to dextrose-treated controls. Means and standard error of the mean are shown with the significance value from Dunnett's multiple comparison tests between groups with five mice per group (*P < 0.05; **P < 0.01; ***P < 0.001).
Lantow et al. Arthritis Research & Therapy 2013 15:R49 doi:10.1186/ar4208