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Open Access Highly Accessed Research article

Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus

Ram Raj Singh123*, Jun-Qi Yang1, Peter J Kim1 and Ramesh C Halder1

Author Affiliations

1 Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), 1000 Veteran Avenue, Los Angeles, CA 90095-1670, USA

2 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 924 Westwood Blvd, Los Angeles, CA 90095, USA

3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Factor Building, Los Angeles, CA 90095, USA

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Arthritis Research & Therapy 2013, 15:R47  doi:10.1186/ar4206

Published: 27 March 2013

Additional files

Additional file 1:

Table S1: A table showing the renal biopsy scoring system. Scales for scores, indices and individual components. Figure S1: A figure showing that the reduction in anti-cardiolipin antibody levels in CD1d° mice is not due to a lack of anti-cardiolipin B cell repertoire in these mice. Anti-cardiolipin antibody levels in cultured supernatants of spleen cells stimulated with lipopolysaccharide (LPS) from wild-type (WT) and CD1d-deficient (CD1d°) mice.

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