Table 5

Summary of association between region of interest activity and cognitive domain z-scores under formal neuropsychological testing

fMRI paradigm

Region of interest

Attention

domain

VCA

domain

Working memory domain


Working memory: N-back

Frontal mid inf R

0.51

Precuneus

0.47

0.54

Parietal inf R

0.45


Attention: CTP-IP

Frontal mid L

-0.45

Insula + temporal sup L

-0.46

SMA + cingulate mid bilateral

-0.47

Fusiform +occipital inf L

0.52


VCA: match vs. motor contrast

Frontal sup L

0.45

Parietal sup L

0.48

Fusiform + occipital inf R

0.45

Angular R

0.51


VCA: SC vs. motor contrast

Frontal mid L

0.45

Frontal sup L

0.64

Frontal sup R

0.49

0.65

Precuneus bilateral

0.54

0.62

Parietal sup L

0.50

0.56

Parietal sup R

0.48

Fusiform + occipital inf L

0.52

Fusiform + occipital inf R

0.48


Values are partial correlation coefficients (r-values). Only r- values > 0.45 are shown, corresponding to P < 0.05. fMRI, functional magnetic resonance imaging; CPT-IP: continuous performance task-identical pairs; VCA, visuoconstructive ability; SC, square completion; L, left; R, right; inf, inferior; sup, superior; mid, middle; SMA, supplementary motor area.

DiFrancesco et al. Arthritis Research & Therapy 2013 15:R40   doi:10.1186/ar4197

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