Table 4

Regions of interest with significant differences in activation between cSLE patients with versus without neurocognitive dysfunction

Anatomical region of interest

no-NCD group

NCD group

p-value


Working memory/N-back

Precuneus

1.05 ± 0.17

0.13 ± 0.25

0.004

Parietal inf L

2.32 ± 0.32

1.10 ± 0.47

0.030

Parietal inf R

3.22 ± 0.41

1.77 ± 0.59

0.041

Attention/CPT-IP

Insula + temporal sup L

0.45 ± 0.19

1.06 ± 0.27

0.050

VCA/match-motor contrast

Frontal inf L

0.71 ± 0.12

0.25 ± 0.17

0.032

Frontal mid L

0.72 ± 0.12

0.26 ± 0.18

0.029

Frontal sup L

0.50 ± 0.10

0.15 ± 0.14

0.037

Parietal inf +supramarginal L

1.19 ± 0.16

0.66 ± 0.23

0.050

Parietal sup L

1.62 ± 0.23

0.81 ± 0.34

0.045

Fusiform+occipital inf L

1.58 ± 0.27

0.59 ± 0.40

0.038

Fusiform+occipital inf R

1.49 ± 0.26

0.52 ± 0.39

0.036

VCA/square-motor contrast

Frontal sup R

0.54 ± 0.09

0.21 ± 0.13

0.033

Precuneus bilateral

0.85 ± 0.14

0.34 ± 0.20

0.036

Fusiform+occipital inf L

1.95 ± 0.24

1.06 ± 0.35

0.033

Fusiform+occipital inf R

1.54 ± 0.22

0.77 ± 0.33

0.048


Region of interest (ROI) activation is defined as the (sum of T-scores within the ROI among voxels with T-scores > 1.66 that are part of clusters of at least 10 voxels)/total voxels in the ROI. cSLE, childhood-onset systemic lupus erythematosus; NCD, neurocognitive dysfunction; CPT-IP: continuous performance task- identical pairs; VCA, visuoconstructive ability; L, left; R, right; inf, inferior; mid, middle.

DiFrancesco et al. Arthritis Research & Therapy 2013 15:R40   doi:10.1186/ar4197

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