Open Access Research article

Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus

Mark W DiFrancesco1*, Darren R Gitelman23, Marisa S Klein-Gitelman4, Anna Carmela P Sagcal-Gironella5, Frank Zelko6, Dean Beebe7, Todd Parrish3, Jessica Hummel5, Jun Ying8 and Hermine I Brunner5

Author Affiliations

1 Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Ave., Cincinnati, OH 45229, USA

2 Department of Neurology, Feinberg School of Medicine, Northwestern University, 420 East Superior St., Chicago, IL 60611, USA

3 Department of Radiology, Feinberg School of Medicine, Northwestern University, 420 East Superior St., Chicago, IL 60611, USA

4 Division of Rheumatology, Ann & Robert Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, 420 East Superior St., Chicago, IL 60611, USA

5 Division of Rheumatology, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Ave., Cincinnati, OH 45229, USA

6 Department of Child and Adolescent Psychiatry, Ann & Robert Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, 420 East Superior St., Chicago, IL 60611, USA

7 Division of Behavioral Medicine and Child Psychology, Cincinnati Children's Hospital Medical Center (CCHMC), 3333 Burnet Ave., Cincinnati, OH 45229, USA

8 Department of Public Health, University of Cincinnati, 2600 Clifton Ave., Cincinnati, OH 45221, USA

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Arthritis Research & Therapy 2013, 15:R40  doi:10.1186/ar4197

Published: 7 March 2013

Additional files

Additional file 1:

Summary of brain activity vs. NCD status for all regions of interest examined. A table listing mean region of interest (ROI) activation, defined as (sum of T-scores within the ROI among voxels with T-scores > 1.66 that are part of clusters of at least 10 voxels)/total voxels in the ROI, for systemic lupus erythematosus (SLE) patients with and without neurocognitive dysfunction (NCD).

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