Table 2

Correlation between transcript levels for TLR7 signaling molecules, and disease activity score and serum cytokine levels in AOSD and SLE patients

AOSD patients

TLR7

MyD88

TRAF6

IRAK4

IRF5

IFN-α


Activity score

0.766***

0.493*

0.481*

0.488*

0.151

0.489*

MyD88 transcript

0.818***

--

TRAF6 transcript

0.742***

0.789***

--

IRAK4 transcript

0.701**

0.746***

0.986***

--

IRF5 transcript

0.241

0.223

0.231

0.218

--

IFN-α transcript

0.713**

0.738***

0.988***

0.986***

0.254

--

Serum IL-1β level

0.626**

0.424

0.589*

0.531*

-0.131

0.556*

Serum IL-6 level

0.589*

0.571*

0.476*

0.434

-0.131

0.455

Serum IL-18 level

0.732**

0.531*

0.451

0.459

-0.033

0.408

Serum TNF-α level

0.117

0.030

0.104

0.059

-0.094

0.036

Serum IFN-α level

0.482*

0.517*

0.558*

0.589*

-0.429

0.571*


SLE patients

TLR7

MyD88

TRAF6

IRAK4

IRF5

IFN-α


SLEDAI score

0.782**

0.731*

0.486

0.517

0.355

0.698*

MyD88 transcript

0.806**

--

TRAF6 transcript

0.564

0.842***

--

IRAK4 transcript

0.515

0.685*

0.939***

--

IRF5 transcript

0.115

-0.236

-0.152

0.127

--

IFN-α transcript

0.661*

0.855***

0.976***

0.952***

-0.139

--

Serum IL-1β level

0.661*

0.334

0.298

0.225

-0.103

0.274

Serum IL-6 level

0.624

0.134

0.036

0.012

-0.024

0.036

Serum IL-18 level

0.770**

0.770**

0.648*

0.588

-0.055

0.721*

Serum TNF-α level

0.261

0.219

0.413

0.547

-0.292

0.474

Serum IFN-α level

0.212

0.456

0.359

0.444

-0.395

0.298


AOSD, adult-onset Still's disease; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index; MyD88, Myeloid differentiation primary-response protein 88; TRAF6, TNF receptor associated factor-6; IRAK4, IL-1 receptor-associated kinase-4; IRF5, interferon regulatory factor-5. *P <0.05, **P <0.01, ***P <0.001 (Spearman's rank correlation test).

Chen et al. Arthritis Research & Therapy 2013 15:R39   doi:10.1186/ar4193

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