Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis'
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology of China Education Ministry, Hefei 230032, Anhui Province, PR China
Arthritis Research & Therapy 2013, 15:405 doi:10.1186/ar4195
See related research by Shi et al., http://arthritis-research.com/content/14/5/R223, and related letter by Shi et al., http://arthritis-research.com/content/15/2/406Published: 3 April 2013
First paragraph (this article has no abstract)
We read with great interest the recent issue of Arthritis Research & Therapy in which Shi and colleagues  investigated the effects of ramipril on oxidative stress and fibrosis in the heart of rats with adjuvant arthritis. The authors concluded that ramipril reversed arthritis scoring and decreased markers of oxidative stress, inflammation, and tissue fibrosis. Undoubtedly, their findings will promote the attempt to diminish the cardiovascular risk of patients with rheumatoid arthritis (RA) by using angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) or both.