Table 1

miRNA players in regulation of innate immunity

miRNA

Target

Regulated process

References


Ligand/cytokine

Receptor

Signaling component

Transcription factor

Others


let-7e

TLR4

Endotoxin sensitivity and tolerance

[53]

miR-106a

IL-10

AML1

Monocyte differentiation, IL-10 production

[32,77]

miR-125b

TNFα

TNFα production by macrophages

[55]

miR-142-3p

IL-6

IL-6 production by DCs

[76]

miR-145

MAL

TLR2-mediated and TLR4-mediated signaling

[63]

miR-146a

IRAK1, IRAK2, TRAF6

IRF5, STAT1

NF-κB-mediated inflammatory response, type I interferon induction and signaling

[39-41,43,44,47]

miR-148a/b

CaMKIIα

DC activation/antigen presentation

[66]

miR-15

IKKα

Monocyte differentiation

[34]

miR-152

CaMKIIα

DC activation/antigen presentation

[66]

miR-155

IKKε MyD88 TAB2

PU.1, C/EBPβ, c-Fos

KPC1 SOCS1 SHIP1

DC development/maturation granulocyte/monocyte expansion endotoxin sensitivity and tolerance

[6,38,45,50-60,92]

BCL6

NF-κB-mediated inflammatory response, AKT signaling and inflammation, type I interferon induction and signaling

miR-155*

IRAKM

Type I interferon induction

[6]

miR-16

IKKα

Monocyte differentiation

[34]

miR-17-5p

AML1

Monocyte differentiation

[32]

miR-187

IκBζ

IL-10-driven anti-inflammatory response

[71]

miR-19a/b

TLR2

TLR2-triggered inflammatory response

[73]

miR-200b/c

MyD88

NF-κB-mediated inflammatory response

[65]

miR-20a

AML1

Monocyte differentiation

[32]

miR-21

JAG1

PDCD4

DC development/maturation, NF-κB-mediated inflammatory response

[35,64]

miR-221

p27

DC development/maturation

[36,59]

miR-223

IKKα, NLRP3

MEF2C STAT3

Monocyte differentiation, granulocyte proliferation/activation, TLR-induced IL-6/IL-1β production

[34,37,69,74,75]

NLRP3 inflammasome response

miR-23b

TAB2, TAB3, IKKα

IL-17-triggered, TNFα-triggered, and IL-1β-triggered inflammatory response

[67]

miR-29

IFNγ

IFNγ production and NK cell activation

[78]

miR-34a

JAG1

DC development/maturation

[35]

WNT1

miR-424

NFI-A

Monocyte differentiation

[33]

miR-9

NFKB1

NF-κB-mediated inflammatory response

[70]


AML1, acute myeloid leukemia-1; C/EBPβ, CCAAT/enhancer binding protein beta; DC, dendritic cell; IFN, interferon; IRAK, IL-1 receptor-associated kinase; IRF, IFN regulatory factor; IKK, I-kappa-B kinase; MAL, MyD88 adapter-like; NK, natural killer; NLRP3, NLR family PYD-containing protein 3; SHIP1, SH2 domain-containing inositol phosphatase-1; STAT, signal transducer and activator of transcription; TAB, TAK1-binding protein; TLR, toll-like receptor; TRAF, TNF receptor-associated factor.

Luo et al. Arthritis Research & Therapy 2013 15:210   doi:10.1186/ar4194