Table 1

Aberrant epigenetic machinery in rheumatoid arthritis and systemic lupus erythematosus

Enzyme

Alternative symbol

Observation

Disease setting

Cell type

Reference


DNMT1

Decreased

SLE

WBCs

[10,12,13]

SLE

CD4+ T cells

[15]

RA

DNMT3B

Decreased

SLE

WBCs

[10]

KAT2B

PCAF

Increased

SLE

PBMCs

[28]

KAT3A

CBP

Decreased

SLE

CD4+ T cells

[27]

KAT3B

P300

Decreased

SLE

CD4+ T cells

[27]

HDAC1

Increased

SLE

PBMCs

[20]

FLSs

[21]

Decreased

FLS

Synovial tissues

[22]

HDAC2

Decreased

SLE

CD4+ T cells

[27]

HDAC4

Altered sumoylation

RA

FLSs

[23]

HDAC7

Decreased

SLE

CD4+ T cells

[27]

HDAC9

Increased

SLE

CD4+ T cells

[24]

SIRT1

Increased

SLE

CD4+ T cells

[27]

KMT?

SETD6

Decreased

RA

PBMCs

[26]

JIA

KMT1B

SUV39H2

Decreased

SLE

CD4+ T cells

[27]

KMT6

EZH2

Decreased

SLE

CD4+ T cells

[27]

Increased

RA

FLSs

[25]

KDM6B

JMJD3

Decreased

SLE

CD4+ T cells

[29]


CBP, CREB-binding protein; DNMT, DNA methyltransferase; EZH2, enhancer of Zeste, Drosophila, Homolog 2; FLS, fibroblast-like synoviocyte; HDAC, histone deacetylase; JIA, juvenile idiopathic arthritis; JMJD3, Jumonji domain-containing protein 3; KAT, K-acetyltransferase; KDM6B, lysine-specific demethylase 6B; KMT, K-methyltransferase; PBMC, peripheral blood mononuclear cell; PCAF, p300/CBP-associated factor; RA, rheumatoid arthritis; SETD6, SET domain containing 6; SIRT1, Sirtuin 1; SLE, systemic lupus erythematosus; SUV39H2, suppressor of variegation 3-9, Drosophila, Homolog of, 2; WBC, white blood cell.

Gray Arthritis Research & Therapy 2013 15:207   doi:10.1186/ar4167