Table 1

Clinically significant upper- and lower-GI events (CSULGIEs) composite end point

With lesion

Without lesion

GD hemorrhage

Acute hemorrhage of unknown origin, including presumed small bowel hemorrhage

Gastric-outlet obstruction

Clinically significant anemia of presumed occult GI origin, including possible small bowel blood loss

GD, small-bowel, or large-bowel perforation

Large-bowel hemorrhage

Small-bowel hemorrhage

Small-bowel obstruction

Clinically significant anemia of defined GI origin

Symptomatic ulcers

GD, gastroduodenal; GI, gastrointestinal.

Moore et al. Arthritis Research & Therapy 2013 15:R6   doi:10.1186/ar4134