Table 1

Clinically significant upper- and lower-GI events (CSULGIEs) composite end point

With lesion

Without lesion


GD hemorrhage

Acute hemorrhage of unknown origin, including presumed small bowel hemorrhage


Gastric-outlet obstruction

Clinically significant anemia of presumed occult GI origin, including possible small bowel blood loss


GD, small-bowel, or large-bowel perforation


Large-bowel hemorrhage


Small-bowel hemorrhage


Small-bowel obstruction


Clinically significant anemia of defined GI origin


Symptomatic ulcers


GD, gastroduodenal; GI, gastrointestinal.

Moore et al. Arthritis Research & Therapy 2013 15:R6   doi:10.1186/ar4134

Open Data