Research article
MMP13 is a critical target gene during the progression of osteoarthritis
1 Department of Orthopedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
2 Current address: Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., PO Box 208020, New Haven, CT 06520, USA
3 Current address: Molecular and Cellular Pharmacology, Abbott, 100 Research Drive, Worcester, MA 01605, USA
4 Institute of Orthopedics and Traumatology, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou 310053, Zhejiang Province, China
5 Department of Biochemistry, Rush University Medical Center, Chicago, 1735 West Harrison Street, IL 60612, USA
6 Liaoning University of Traditional Chinese Medicine, 79 East Chongshan Road, Huanggu District, Shenyang 110847, Liaoning Province, China
Arthritis Research & Therapy 2013, 15:R5 doi:10.1186/ar4133
Published: 8 January 2013Additional files
Additional file 1:
Deletion of the Mmp13 gene in chondrocytes at the postnatal stage has no significant effect on articular and growth plate cartilage morphology. Histological sections from 10-week-old Cre-negative control and matrix metalloproteinase (MMP13) conditional knockout (cKO) mice (Mmp13Col2ER) treated with or without tamoxifen (tamoxifen was administered to two-week-old mice) were stained with Alcian blue/Hematoxylin/Orange G. No significant changes in articular and growth plate cartilage morphology were observed in these mice.
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