Regulatory T cells (Treg) prolong drug-induced disease remission. (A-D) Changes in clinical parameters and survival of (NZBxNZW) F1 mice with active disease after induction of remission with glucocorticosteroid (GC)/cyclophosphamide (CTX) and after an additional adoptive transfer of 1.5 × 106 Treg/mouse (Treg) compared to age-matched mice that received only GC/CTX and PBS (Control). (A-C) Average proteinuria score (A), leukocyturia score (B) and levels of antibodies against ds-DNA (C) determined at the indicated time points during the study. Error bars indicate standard error of the mean (SEM) (*P <0.05; Treg vs Control at the indicated time point). (D) Survival time is presented as a Kaplan-Meier curve (P = 0.01; Treg vs Control). (A-D) Data are the summary of two to three independent experiments, with eight to ten mice per group in total.
Weigert et al. Arthritis Research & Therapy 2013 15:R35 doi:10.1186/ar4188