Table 7

Change in fatigue in lean, overweight and obese patients versus change in adipokines, IGF-1 and neuropeptides

Lean patients

∆MFIGF

30 wks

∆Adiponectin

30 wks

∆Leptin

30 wks

∆Resistin

30 wks

∆Free IGF-1

30 wks

∆Tot IGF-1

30 wks

∆IGFB3

30 wks

∆NPY

30 wks

∆NGF

30 wks


∆FIQ Fatigue

30 weeks

r

P

n

0.268

0.521

8

0.541

0.210

7

-0.432

0.333

7

-0.685

0.090

7

0.145

0.784

6

0.812

0.05

6

0.086

0.872

6

1.000

2

1.000

2

∆MFIGF

30 weeks

r

P

n

1.000

8

0.275

0.550

7

-0.220

0.635

7

-0.239

0.606

7

0.059

0.912

6

0.706

0.117

6

0.177

0.738

6

1.000

2

1.000

2


Overweight patients

∆MFIGF

30 wks

∆Adiponectin

30 wks

∆Leptin

30 wks

∆Resistin

30 wks

∆Free IGF-1

30 wks

∆Tot IGF-1

30 wks

∆IGFB3

30 wks

∆NPY

30 wks

∆NGF

30 wks


∆FIQ Fatigue

30 wks

r

P

n

0.530

0.008

24

-0.219

0.315

23

-0.099

0.654

23

0.270

0.213

23

-0.021

0.924

22

0.213

0.380

19

0.260

0.232

23

0.394

0.164

14

-0.475

0.086

14

∆MFIGF

30 wks

r

P

n

1.000

24

-0.089

0.685

23

0.127

0.562

23

-0.265

0.222

23

-0.233

0.297

22

-0.012

0.962

19

0.104

0.635

23

0.384

0.176

14

-0.047

0.874

14


Obese patients

∆MFIGF

30 wks

∆Adiponectin

30 wks

∆Leptin

30 wks

∆Resistin

30 wks

∆Free IGF-1

30 wks

∆Tot IGF-1

30 wks

∆IGFB3

30 wks

∆NPY

30 wks

∆NGF

30 wks


∆FIQ Fatigue

30 wks

r

P

n

0.283

0.373

12

-0.753

0.019

9

0.084

0.831

9

-0.326

0.391

9

-0.711

0.032

9

-0.261

0.498

9

0.072

0.878

7

0.154

0.805

5

-0.205

0.741

5

∆MFIGF

30 wks

r

P

n

1.000

12

-0.210

0.587

9

0.647

0.060

9

-0.815

0.007

9

-0.025

0.949

9

-0.418

0.263

9

0.786

0.036

7

-0.900

0.037

5

0.500

0.391

5


Correlation after 30 weeks between change (∆) in fatigue (∆FIQ and ∆MFIGF) and change in serum free IGF-1, serum levels of IGFB3, adipokines and neuropeptides in lean patients, overweight and obese patients. r, Spearman's correlation coefficient; P, P-value; n, number; FIQ, Fibromyalgia Impact Questionnaire; MFIGF, Multidimensional Fatigue Inventory subscale of General Fatigue; IGF, insulin-like growth factor; IGFB3, insulin-like growth factor-binding protein-3; NGF, nerve growth factor; NPY, neuropeptide Y.

Bjersing et al. Arthritis Research & Therapy 2013 15:R34   doi:10.1186/ar4187

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