Table 6

Change in fatigue versus change in adipokines, IGF-1 and neuropeptides

∆MFIGF

30 wks

∆Adiponectin

30 wks

∆Leptin

30 wks

∆Resistin

30 wks

∆Free IGF-1

30 wks

∆Total IGF-1

30 wks

∆IGFB3

30 wks

∆NGF

30 wks

∆NPY

30 wks


∆FIQ fatigue

30 wks

r

P

n

0.415

0.005

44

-0.227

0.164

39

-0.111

0.502

39

-0.016

0.923

39

-0.147

0.385

37

0.106

0.549

34

0.250

0.141

36

-0.463

0.034

21

0.469

0.032

21

∆MFIGF

30 wks

r

P

n

1.000

44

-0.096

0.561

39

0.280

0.084

39

-0.346

0.031

39

-0.201

0.232

37

-0.075

0.672

34

0.382

0.022

36

0.043

0.852

21

0.209

0.364

21

∆Adiponectin

30 wks

r

P

n

1.000

41

-0.016

0.922

41

0.011

0.943

41

0.002

0.989

39

0.091

0.600

36

-0.241

0.145

38

0.097

0.669

22

-0.361

0.099

22

∆Leptin

30 wks

r

P

n

1.000

41

-0.009

0.954

41

-0.211

0.196

39

0.051

0.765

36

-0.058

0.730

38

0.199

0.374

22

-0.091

0.687

22

∆Resistin

30 wks

r

P

n

1.000

41

0.048

0.770

39

-0.186

0.277

36

-0.143

0.393

38

0.103

0.647

22

-0.278

0.210

22

∆Free IGF-1

30 wks

r

P

n

1.000

40

0.103

0.556

35

0.178

0.299

36

0.356

0.104

22

-0.563

0.006

22

∆Total IGF-1

30 wks

r

P

n

1.000

40

0.043

0.812

33

-0.115

0.639

19

-0.128

0.601

19

∆IGFB3

30 wks

r

P

n

1.000

38

-0.089

0.695

22

-0.242

0.277

22

∆NGF

30 wks

r

P

n

1.000

22

-0.215

0.336

22


Correlation after 30 weeks between change (∆) in fatigue (∆FIQ and ∆MFIGF) and change in serum free IGF-1, serum levels of IGFB3, adipokines and neuropeptides. r, Spearman's correlation coefficient; P, P-value; n, number; FIQ, Fibromyalgia Impact Questionnaire; MFIGF, Multidimensional Fatigue Inventory subscale of General Fatigue; IGF, insulin-like growth factor; IGFB3, insulin-like growth factor-binding protein-3; NGF, nerve growth factor; NPY, neuropeptide Y.

Bjersing et al. Arthritis Research & Therapy 2013 15:R34   doi:10.1186/ar4187

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