Table 3

Serum free IGF-1, total IGF-1 and IGFB3 in lean, overweight and obese patients

Lean (group 1)

Overweight (group 2)

Obese (group 3)

Comparison of groups


Baseline

Median (range)

∆15 wks

Median (range)

P-valuea

∆30 wks

Median (range)

P-valuea

Baseline

Median (range)

∆15 wks

Median (range)

P-valuea

∆30 wks

Median (range)

P-valuea

Baseline

Median (range)

∆15 wks

Median (range)

P-valuea

∆30 wks

Median (range)

P-valuea

Groups

At baseline

P-valueb

Change after 15 weeks

P-valueb

Change after 30 weeks

P-valueb


Free

IGF-1

ng/ml

4.3 (2.3 to 4.6)

0.8 (-1.1 to 1.4)

0.1 (-5.5 to 0.9)

3.1 (1.7 to 6.3)

-0.4 (-1.5 to 0.5)

-0.7 (-1.6 to 0.6)

5.7 (3.4 to 8.0)

-1.2 (-4.7 to 0.4)

-2.1 (-4.7 to -0.1)

Lean vs overweight

0.697

0.171

0.900

n = 9

P = 0.515

n = 9

P = 0.753

n = 6

n = 26

P = 0.174

n = 26

P = 0.053

n = 24

n = 13

P = 0.173

n = 13

P = 0.017

n = 10

Lean vs obese

0.164

0.051

0.368

IGFB3

ng/ml

1605.6 (1179.4 to 2397.9)

-260.7 (-578.6 to 36.3)

-568.5 (-899.7 to 123.5)

1492.2 (1079.2 to 1999.4)

106.0 (-370.3 to 942.3)

349.2 (-282.8 to 767.0)

1645.2 (1420.6 to 2002.8)

-19.9 (-622.3 to 544.8)

282.0 (-869.5 to 1558.2)

Lean vs overweight

0.563

0.107

0.095

n = 8

P = 0.093

n = 8

P = 0.249

n = 6

n = 26

P = 0.397

n = 25

P = 0.128

n = 25

n = 10

P = 0.878

n = 10

P = 0.735

n = 7

Lean vs obese

0.897

0.460

0.628

Total

IGF-1

ng/ml

160.0 (123.0 to 187.0)

33.0 (0.0 to 51.0

65.0 (17.8 to 94.3)

113.0 (90.3 to 151.8

10.0 (-13.5 to 19.0)

34.0 (-0.9 to 48.0)

106.5 (95.8 to 157.8)

-1.0 (-21.8 to 4.5)

19.0 (6.0 to 29.0)

Lean vs overweight

0.026

0.065

0.125

n = 7

P = 0.043

n = 7

P = 0.116

n = 24

P = 0.309

n = 17

P = 0.006

n = 12

P = 0.255

n = 12

P = 0.017

Lean vs obese

0.056

0.010

0.036


Levels of serum free IGF-1, total serum IGF-1 and serum IGFB3 at baseline (0 weeks), change () during training (15 weeks) and change after training (30 weeks). Median values and interquartile range are indicated. aWilcoxon signed rank test. bMann-Whitney U-test. IGF-1, insulin-like growth factor-1; IGFB3, insulin-like growth factor-binding protein-3.

Bjersing et al. Arthritis Research & Therapy 2013 15:R34   doi:10.1186/ar4187

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