Table 3 

Serum free IGF1, total IGF1 and IGFB3 in lean, overweight and obese patients 

Lean (group 1) 
Overweight (group 2) 
Obese (group 3) 
Comparison of groups 



Baseline Median (range) 
∆15 wks Median (range) Pvalue^{a} 
∆30 wks Median (range) Pvalue^{a} 
Baseline Median (range) 
∆15 wks Median (range) Pvalue^{a} 
∆30 wks Median (range) Pvalue^{a} 
Baseline Median (range) 
∆15 wks Median (range) Pvalue^{a} 
∆30 wks Median (range) Pvalue^{a} 
Groups 
At baseline Pvalue^{b} 
Change after 15 weeks Pvalue^{b} 
Change after 30 weeks Pvalue^{b} 



Free IGF1 ng/ml 
4.3 (2.3 to 4.6) 
0.8 (1.1 to 1.4) 
0.1 (5.5 to 0.9) 
3.1 (1.7 to 6.3) 
0.4 (1.5 to 0.5) 
0.7 (1.6 to 0.6) 
5.7 (3.4 to 8.0) 
1.2 (4.7 to 0.4) 
2.1 (4.7 to 0.1) 
Lean vs overweight 
0.697 
0.171 
0.900 
n = 9 
P = 0.515 n = 9 
P = 0.753 n = 6 
n = 26 
P = 0.174 n = 26 
P = 0.053 n = 24 
n = 13 
P = 0.173 n = 13 
P = 0.017 n = 10 
Lean vs obese 
0.164 
0.051 
0.368 

IGFB3 ng/ml 
1605.6 (1179.4 to 2397.9) 
260.7 (578.6 to 36.3) 
568.5 (899.7 to 123.5) 
1492.2 (1079.2 to 1999.4) 
106.0 (370.3 to 942.3) 
349.2 (282.8 to 767.0) 
1645.2 (1420.6 to 2002.8) 
19.9 (622.3 to 544.8) 
282.0 (869.5 to 1558.2) 
Lean vs overweight 
0.563 
0.107 
0.095 
n = 8 
P = 0.093 n = 8 
P = 0.249 n = 6 
n = 26 
P = 0.397 n = 25 
P = 0.128 n = 25 
n = 10 
P = 0.878 n = 10 
P = 0.735 n = 7 
Lean vs obese 
0.897 
0.460 
0.628 

Total IGF1 ng/ml 
160.0 (123.0 to 187.0) 
33.0 (0.0 to 51.0 
65.0 (17.8 to 94.3) 
113.0 (90.3 to 151.8 
10.0 (13.5 to 19.0) 
34.0 (0.9 to 48.0) 
106.5 (95.8 to 157.8) 
1.0 (21.8 to 4.5) 
19.0 (6.0 to 29.0) 
Lean vs overweight 
0.026 
0.065 
0.125 
n = 7 
P = 0.043 n = 7 
P = 0.116 
n = 24 
P = 0.309 n = 17 
P = 0.006 
n = 12 
P = 0.255 n = 12 
P = 0.017 
Lean vs obese 
0.056 
0.010 
0.036 



Levels of serum free IGF1, total serum IGF1 and serum IGFB3 at baseline (0 weeks), change (∆) during training (15 weeks) and change after training (30 weeks). Median values and interquartile range are indicated. ^{a}Wilcoxon signed rank test. ^{b}MannWhitney Utest. IGF1, insulinlike growth factor1; IGFB3, insulinlike growth factorbinding protein3. 

Bjersing et al. Arthritis Research & Therapy 2013 15:R34 doi:10.1186/ar4187 