Table 3

Associations between OPN haplotypes and risk of knee OA

Haplotype analysis*

-156G/GG

-443C/T

-66T/G

Cases (frequency)

Controls (frequency)

Chi²

Pearson's P

Odds ratio (95% CI)

G

C

T

166

194.

4.451

0.065

0.789 (0.633, 1.092)

G

T

G

218

262

8.044

0.005

0.754 (0.620, 0.917)

G

C

T

209

206

0.206

0.650

0.953 (0.775, 1.172)

G

T

G

154

177

3.422

0.064

0.806 (0.642, 1.013)

GG

C

T

273

145

37.47

0.000

1.943 (1.566, 2.409)

GG

C

G

222

165

6.324

0.012

1.317 (1.062, 1.633)

GG

T

T

231

210

0.181

0.670

1.045 (0.854, 1.278)

*All haplotypes with frequency < 0.03 are ignored in this analysis.

Jiang et al. Arthritis Research & Therapy 2013 15:R3   doi:10.1186/ar4129