Table 2 |
||||||||||
|
Genotype distributions and allele frequencies of OPN polymorphisms in OA and control subjects |
||||||||||
|
OPN polymorphism |
Allele frequency |
OA patients, n |
% |
Controls, n |
% |
Global P-value |
Adjusted OR |
95% CI |
Adjusted P-value |
|
|
|
||||||||||
|
-156/G/GG |
GG |
203 |
27.07 |
213 |
26.83 |
0.557 |
1 |
|||
|
GGG |
352 |
46.93 |
391 |
49.24 |
0.956 |
0.732 |
1.276 |
0.701 |
||
|
GGGG |
195 |
26.00 |
190 |
23.93 |
1.787 |
0.887 |
1.552 |
0.674 |
||
|
G |
758 |
50.53 |
817 |
51.45 |
0.318 |
1 |
||||
|
GG |
742 |
49.47 |
771 |
48.55 |
1.038 |
0.785 |
1.267 |
0.658 |
||
|
-443C/T |
CC |
167 |
22.27 |
119 |
14.99 |
< 0.001 |
1 |
|||
|
CT |
384 |
51.20 |
405 |
51.01 |
0.763 |
0.457 |
0.998 |
0.003 |
||
|
TT |
199 |
26.53 |
270 |
34.01 |
0.525 |
0.392 |
0.872 |
< 0.001 |
||
|
C |
718 |
47.87 |
643 |
40.49 |
0.018 |
1 |
||||
|
T |
782 |
52.13 |
945 |
59.51 |
0.689 |
0.575 |
0.896 |
< 0.001 |
||
|
-66T/G |
TT |
188 |
25.07 |
153 |
19.27 |
0.013 |
1 |
|||
|
TG |
369 |
49.20 |
402 |
50.63 |
0.738 |
0.516 |
0.988 |
0.035 |
||
|
GG |
193 |
25.73 |
239 |
30.10 |
0.657 |
0.494 |
0.874 |
0.017 |
||
|
T |
745 |
49.67 |
708 |
44.58 |
0.009 |
1 |
||||
|
G |
755 |
50.33 |
880 |
55.42 |
0.876 |
0.765 |
0.876 |
0.011 |
||
|
|
||||||||||
|
OPN, osteopontin; OA, osteoarthritis; OR, odds ratio. |
||||||||||
|
Jiang et al. Arthritis Research & Therapy 2013 15:R3 doi:10.1186/ar4129 |
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