Table 2

Genotype distributions and allele frequencies of OPN polymorphisms in OA and control subjects

OPN polymorphism

Allele frequency

OA patients, n

%

Controls, n

%

Global P-value

Adjusted OR

95% CI

Adjusted P-value


-156/G/GG

GG

203

27.07

213

26.83

0.557

1

GGG

352

46.93

391

49.24

0.956

0.732

1.276

0.701

GGGG

195

26.00

190

23.93

1.787

0.887

1.552

0.674

G

758

50.53

817

51.45

0.318

1

GG

742

49.47

771

48.55

1.038

0.785

1.267

0.658

-443C/T

CC

167

22.27

119

14.99

< 0.001

1

CT

384

51.20

405

51.01

0.763

0.457

0.998

0.003

TT

199

26.53

270

34.01

0.525

0.392

0.872

< 0.001

C

718

47.87

643

40.49

0.018

1

T

782

52.13

945

59.51

0.689

0.575

0.896

< 0.001

-66T/G

TT

188

25.07

153

19.27

0.013

1

TG

369

49.20

402

50.63

0.738

0.516

0.988

0.035

GG

193

25.73

239

30.10

0.657

0.494

0.874

0.017

T

745

49.67

708

44.58

0.009

1

G

755

50.33

880

55.42

0.876

0.765

0.876

0.011


OPN, osteopontin; OA, osteoarthritis; OR, odds ratio.

Jiang et al. Arthritis Research & Therapy 2013 15:R3   doi:10.1186/ar4129

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