CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

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Chun-Han Hou, Chih-Hsin Tang, Chin-Jung Hsu, Sheng-Mon Hou^* and Ju-Fang Liu^*

* Corresponding authors: Sheng-Mon Hou shengmou@ms.skh.org.tw - Ju-Fang Liu anti0822@hotmail.com

Arthritis Research & Therapy 2013, 15:R19 doi:10.1186/ar4151