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Open Access Highly Accessed Research article

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

Chun-Han Hou1, Chih-Hsin Tang23, Chin-Jung Hsu45, Sheng-Mon Hou6* and Ju-Fang Liu7*

Author Affiliations

1 Department of Orthopedic Surgery, National Taiwan University Hospital, 7, Zhongshan South Road, Taipei 100, Taiwan

2 Department of Pharmacology, School of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 402, Taiwan

3 Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 402, Taiwan

4 School of Chinese Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 402, Taiwan

5 Department of Orthopedic Surgery, China Medical University Hospital, 91 Hsueh-Shih Road, Taichung 402, Taiwan

6 Department of Orthopedic Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan

7 Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan

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Arthritis Research & Therapy 2013, 15:R19  doi:10.1186/ar4151

Published: 23 January 2013

Additional files

Additional file 1:

The cell viability of PI3K, Akt, and NF-κB inhibitors in human synovial fibroblasts. OASFs were treated with Wortmannin, Ly294002, Akt inhibitor, PDTC, or TPCK for 24 hours. The cell viability was examined by MTT assay. MTT, 3-(4,5-dmethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; OASFs, osteoarthritis synovial fibroblasts; PDTC, pyrrolidine-dithiocarbamate; TPCK, L-1-tosylamido-2-phenylenylethyl chloromethyl ketone.

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