Table 4

Risk of developing rheumatoid arthritis: Cox regression univariate and multivariate hazards ratio (HR) analysis

HR (95% CI)

Unadjusted

P

HR (95% CI)

Adjusted

P

CRP

Negative

1

1

Low +

0.720 (0.362, 1.434)

0.350

0.875 (0.423, 1.811)

0.719

High+

1.737 (1.049, 2.877)

0.032

1.827 (0.950, 3.514)

0.071

RF

Negative

1

1

Low+

2.020 (1.001, 4.073)

0.050

0.791 (0.248, 2.522)

0.692

High+

3.097 (1.867, 5.137)

< 0.001

0.729 (0.219, 2.431)

0.607

ACPA

Negative

1

1

Low +

3.360 (1.412, 7.998)

0.006

3.187 (1.257, 8.077)

0.015

High +

4.613 (2.698, 7.887)

< 0.001

4.324 (2.023, 9.245)

< 0.001

Hand joints arthritis

1.871 (1.083, 3.232)

0.025

2.140 (1.128, 4.059)

0.020

CRP, C-reactive protein; RF, rheumatoid factor; ACPA, anti-citrullinated peptide antibodies.

Bizzaro et al. Arthritis Research & Therapy 2013 15:R16   doi:10.1186/ar4148