Table 4

Allelic frequencies of the major haplotypes found in RA patients and controls

Haplotypes

Controls

2n = 942

Patients

2n = 930

P-value

P_c-value*

Odds ratio (95% CI)

rs2776377

rs878081

rs2075876

rs1055311

A

C

G

C

0.324

0.331

ns

1.03 (0.85, 1.24)

A

C

G

T

0.182

0.193

ns

1.09 (0.86, 1.38)

G

T

G

C

0.174

0.124

0.0025

0.0141

0.67 (0.52, 0.87)

G

C

G

C

0.110

0.146

0.0182

ns

1.38 (1.05, 1.82)

G

C

A

C

0.106

0.111

ns

1.05 (0.78, 1.40)

A

T

G

C

0.076

0.065

ns

0.84 (0.59, 1.20)

RA, rheumatoid arthritis; ns, not significant at P > 0.05. *P_c-value, 10,000-fold permutation testing.

García-Lozano et al. Arthritis Research & Therapy 2013 15:R11   doi:10.1186/ar4141