Table 2

Allelic frequencies of the SNPs studied in the AIRE in RA Spanish patients and controls

SNP

(location)

Allele

Controls

2n = 942

Patients

2n = 930

P-value

Pc-value^a

Odds ratio (95% CI)

Japanese population^b

rs2776377

(5'UTR)

A

0.589

0.597

ns

0.265^c

rs878081

(exon 5)

C

0.746

0.805

0.0022

0.0123

1.41 (1.13, 1.75)

0.827^c

rs2075876

(intron 5)

A

0.114

0.116

ns

0.340^d

rs1055311

(exon 6)

T

0.206

0.219

ns

0.012^c

rs1800520

(exon 7)

G

0.017

0.019

ns

0.420^d

RA, rheumatoid arthritis; SNP, single-nucleotide polymorphism, UTR: unstranlated region, ns: not significant at P > 0.05. ^aP_c-value, 10,000-fold permutation testing; ^bAllelic frequencies in the Japanese population; ^cHapMap Project, JPT (Japanese in Tokyo) population; ^dTerao et al. 2011 [4].

García-Lozano et al. Arthritis Research & Therapy 2013 15:R11   doi:10.1186/ar4141