Estradiol and estrone levels are increased in serum of patients with diffuse cutaneous systemic sclerosis. Dot plots of serum levels of estradiol and estrone in patients with diffuse cutaneous systemic sclerosis (SSc) and healthy controls. Measurements were made using 68 patients with SSc and 35 healthy controls. Differences in estradiol levels were not significant whereas estrone levels were statistically significant (P = 0.002).
Aida-Yasuoka et al. Arthritis Research & Therapy 2013 15:R10 doi:10.1186/ar4140