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Editorial

The butterfly rash of lupus: An example of aposematism?

David S Pisetsky

Author affiliations

Duke University Medical Center, 151G, Durham VA Medical Center, Durham, NC 27705, USA

Citation and License

Arthritis Research & Therapy 2013, 15:106  doi:10.1186/ar4155

Published: 19 February 2013

First paragraph (this article has no abstract)

Even the most seasoned and savvy clinician views lupus warily, considering it one of the most bewildering diseases in all of medicine. This situation should not be a surprise since the manifestations of lupus are dizzying in their variety and exasperating in their subtlety. Furthermore, although lupus has been at the heart of immunology research for decades, investigators have yet to figure out its basis. Lupus represents a blatant violation of the most fundamental laws of the immune system. Nevertheless, the disturbances that dangerously turn self into non-self remain totally obscure.