Table 3

Human conditions associated with altered CD19 expression

CD19 upregulation

CD19 downregulation


Systemic sclerosis (MFI)

SLE (MFI)

SLE (CD19high B cells)

CD19 deficiency

CVID, HIV (CD19high B cells)

Heterozygous mutation in CD19

BCR deficiency (CD19high B cells)

CD81 deficiency

Mutations in Bruton's tyrosine kinase


BCR, B-cell receptor; CVID, common variable immunodeficiency; MFI, mean fluorescence intensity; SLE, systemic lupus erythematosus.

Mei et al. Arthritis Research & Therapy 2012 14(Suppl 5):S1   doi:10.1186/ar3909