Table 3 |
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Human conditions associated with altered CD19 expression |
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CD19 upregulation |
CD19 downregulation |
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Systemic sclerosis (MFI) |
SLE (MFI) |
|
SLE (CD19high B cells) |
CD19 deficiency |
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CVID, HIV (CD19high B cells) |
Heterozygous mutation in CD19 |
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BCR deficiency (CD19high B cells) |
CD81 deficiency |
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Mutations in Bruton's tyrosine kinase |
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|
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BCR, B-cell receptor; CVID, common variable immunodeficiency; MFI, mean fluorescence intensity; SLE, systemic lupus erythematosus. |
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Mei et al. Arthritis Research & Therapy 2012 14(Suppl 5):S1 doi:10.1186/ar3909 |
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