Table 2 |
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|
|
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|
Subgroup |
Thrombotic events |
Rate of events/1,000 person-years |
Rate ratios (95% CI) |
P value |
|
|
|
|||||
|
Current prednisone |
None |
52 |
10.6 |
1.0 (Ref. Gp) |
|
|
1 to 9 mg/day |
40 |
16.4 |
1.6 (1.1 to 2.4) |
0.025 |
|
|
10 to 19 mg/day |
49 |
34.3 |
3.3 (2.2 to 4.8) |
<0.0001 |
|
|
20+ mg/day |
43 |
71.8 |
6.5(4.3 to 9.8) |
<0.0001 |
|
|
Cumulative prednisone dose |
None |
29 |
13.1 |
1.0 (Ref. Gp) |
|
|
<1 year (10 mg/day) |
37 |
23.8 |
1.6 (1.0 to 2.6) |
0.075 |
|
|
1 to 3 years (10 mg/day) |
30 |
19.0 |
1.8 (1.1 to 3.1) |
0.026 |
|
|
3 to 10 years (10 mg/day) |
45 |
25.5 |
3.0 (1.8 to 5.2) |
<0.0001 |
|
|
>10 years (10 mg/day) |
9 |
24.3 |
3.7 (1.5 to 9.4) |
0.0056 |
|
|
Current HCQ |
No |
95 |
29.0 |
1.0 (Ref. Gp) |
|
|
Yes |
90 |
14.6 |
0.5 (0.4 to 0.7) |
<0.0001 |
|
|
HCQ use |
Never |
57 |
32.2 |
1.0 (Ref. Gp) |
|
|
Past (not current) |
27 |
27.6 |
0.9 (0.6 to 1.5) |
0.81 |
|
|
<6 consecutive months |
16 |
20.0 |
0.6 (0.3 to 1.0) |
0.056 |
|
|
>6 consecutive months |
64 |
13.8 |
0.5 (0.3 to 0.7) |
0.0003 |
|
|
NSAID use |
No |
146 |
21.6 |
1.0 (Ref. Gp) |
|
|
Yes |
37 |
13.9 |
0.6 (0.4 to 0.9) |
0.017 |
|
|
Aspirin use |
No |
137 |
17.9 |
1.0 (Ref. Gp) |
|
|
Yes |
49 |
28.0 |
1.6 (1.2 to 2.3) |
0.0038 |
|
|
|
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|
Petri Arthritis Research & Therapy 2012 14(Suppl 3):A52 doi:10.1186/ar3986 |
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