This article is part of the supplement: Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)
LC-MS/MS-based shotgun proteomics identified the targets of arthritis-related microRNA
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* Corresponding author: Riho Kurata riho@hope.tokai-u.jp
1 Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo 157-8535, Japan
2 Department of Molecular Life Sciences, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
3 Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo 157-8535, Japan
4 Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
5 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Saitama 332-0012, Japan
Arthritis Research & Therapy 2012, 14(Suppl 1):P36 doi:10.1186/ar3637
Published: 9 February 2012First paragraph (this article has no abstract)
microRNAs (miRNAs), which are class of post-transcriptional regulators such as short 19 to 23-nucleotide non-coding RNAs, complementarily bind seed sequences in the 3'-untranslational region of multiple target mRNAs, resulting in their suppression of translation or degradation [1]. In the former case, since the mRNA expression of the targets does not any change, transcriptomics approach, such as expression array, cannot identify the targets.