Table 2 |
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|
Pooled analysis and stratified analyses of SSc patients and healthy controls for rs10744676 genetic variant, located in the KCNA5 gene |
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|
Genotype, n (%) |
Allele test |
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|
|
|
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|
Subgroup (n) |
C/C |
C/T |
T/T |
MAF (%) |
PMH |
OR (95% CI) |
PBD |
|
|
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|
Controls (n = 2,690) |
37 (1.38) |
597 (22.19) |
2,056 (76.43) |
12.47 |
|||
|
SSc (n = 2,343) |
43 (1.84) |
471 (20.10) |
1,829 (78.06) |
11.89 |
0.49 |
0.96 (0.85-1.08) |
0.53 |
|
lcSSc (n = 1,642) |
31 (1.89) |
327 (19.91) |
1,284 (78.20) |
11.85 |
0.48 |
0.95 (0.83-1.09) |
0.63 |
|
dcSSc (n = 701) |
12 (1.71) |
144 (20.54) |
545 (77.75) |
11.98 |
0.80 |
0.98 (0.81-1.17) |
0.59 |
|
ACA+ (n = 931) |
18 (1.93) |
197 (21.16) |
716 (76.91) |
12.51 |
0.49 |
1.06 (0.90-1.24) |
0.96 |
|
ATA+ (n = 568) |
8 (1.41) |
117 (20.60) |
443 (77.99) |
11.71 |
0.85 |
0.98 (0.80-1.20) |
0.94 |
|
Fib+ (n = 771) |
14 (1.82) |
154 (19.97) |
603 (78.21) |
11.80 |
0.34 |
0.92 (0.77-1.09) |
0.92 |
|
PAH+ (n = 179) |
2 (1.12) |
37 (20.67) |
140 (78.21) |
11.45 |
0.44 |
0.88 (0.63-1.23) |
0.70 |
|
|
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|
MAF, minor allele frequency; PMH, Mantel-Haenszel test under fixed-effect P values. Controls are used as reference for all comparisons, and P values have been calculated for the allelic model. OR, odds ratio for the minor allele; 95% CI, 95% confidence interval; SSc, systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA+, anti-centromere autoantibody-positive patient; ATA+, anti-topoisomerase autoantibody-positive patient; Fib+, lung fibrosis-positive patient (HRCT); PAH+, pulmonary arterial hypertension-positive patients (right-heart catheterization). |
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|
Bossini-Castillo et al. Arthritis Research & Therapy 2012 14:R273 doi:10.1186/ar4124 |
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