Table 1

Overall statistical power of the study for KCNA5 rs10744676 SNP in each analyzed disease subtype at the 5% significance level assuming an additive effect model and a minor allele (rs10744676*C) frequency = 0.10 (MAFCEU)

Phenotype


Statistical power (%)

SSc

lcSSc

dcSSc

ACA+

ATA+

Fib+

PAH+


OR = 0.62

100

100

99

100

96

99

95a

OR = 0.48

100

100

100

100

100

100

100b

OR = 0.79

96

91

67

77

59

71

45c


aReference OR, 0.62, except for the PAH+ group, in which OR = 0.47. bReference OR (lower previously reported 95% CI) = 0.48, except for the PAH+ group, in which OR = 0.32. cReference OR (upper previously reported 95% CI) = 0.79, except for the PAH+ group, in which OR = 0.71. SSc, systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA+, anti-centromere autoantibody-positive patients; ATA+, anti-topoisomerase autoantibody-positive patients; Fib+, lung fibrosis-positive patients (HRCT); PAH+, pulmonary arterial hypertension-positive patients (right-heart catheterization).

Bossini-Castillo et al. Arthritis Research & Therapy 2012 14:R273   doi:10.1186/ar4124

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