Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Open Access Highly Accessed Research article

Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes

Linghui Dai1, Xin Zhang1, Xiaoqing Hu1, Chunyan Zhou2* and Yingfang Ao1*

Author Affiliations

1 Institute of Sports Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, P. R. China

2 Department of Biochemistry and Molecular Biology, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Haidian District, Beijing 100191, P. R. China

For all author emails, please log on.

Arthritis Research & Therapy 2012, 14:R268  doi:10.1186/ar4114

Published: 10 December 2012

Additional files

Additional file 1:

Supplemental figures and figure legends. This file contains 5 figures (Figure S1-S5) and their figure legends. Figure S1: Relative miR-145 expression levels at present of IL-1β in primary rat chondrocytes. Figure S2: miR-101 has an IL-1β concentration dependent effect in primary chondrocyte. Figure S3: miR-101 and the pri-miR-101 expression level. Figure S4: Morphological changes of the chondrocytes post miRNA transfection and IL-1β treatment. Figure S5: Effect of miR-101 transfection on the components of IL-1β signaling.

Format: PDF Size: 15MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data