The effects of Fn and cFn on the secretion of TNF-α, IL-1 and IL-17 by FLSs isolated from RA or OA patients. RA or OA FLSs were treated with Fn or cFn at 2 μg/ml for 72 h and the supernatants were collected for the analysis of TNF-α, IL-1 and IL-17 levels. RA (n = 8) and OA (n = 6) * P < 0.05, ** P < 0.01, and NS, not significant. cFn, citrullinated fibronectin; FLSs, fibroblast-like synoviocytes; Fn, fibronectin; IL, interleukin; OA, osteoarthritis; RA, rheumatoid arthritis; TNF-α, tumor necrosis factor alpha.
Fan et al. Arthritis Research & Therapy 2012 14:R266 doi:10.1186/ar4112