Figure 2.

The effects of Fn and cFn on the apoptosis of FLSs isolated from RA or OA patients. The isolated FLSs from RA and OA patients were treated for 72 h as indicated and the apoptosis was detected by Annexin V-FITC/PI (A) and TUNEL analysis (B). RA (n = 8) and OA (n = 6) * P < 0.05, ** P < 0.01, and NS, not significant. cFn, citrullinated fibronectin; FITC, fluorescein isothiocyanate; FLSs, fibroblast-like synoviocytes; Fn, fibronectin; OA, osteoarthritis; PI, propidium iodide; RA, rheumatoid arthritis; TUNEL, terminal deoxyribonucleotidyl transferase mediated dUTP nick-end labeling.