Table 1

Effect of collagen coating on IL-6 and cartilage matrix production

Col I

Col II

Col ID

Col IID

P-value


IL-6 (pg/ml)

4,294 ± 2,152

4,604 ± 1,661

4,268 ± 1,446

5,463 ± 1,991

0.543

GAG (μg)

80 ± 24

85 ± 30

77 ± 25

85 ± 34

0.361

GAG release (μg/ml)

408 ± 29

410 ± 35

400 ± 38

498 ± 157

0.412

DNA (μg)

10 ± 1

9 ± 1

10 ± 2

10 ± 1

0.818


No significant differences were observed between type I collagen (Col I), type II collagen (Col II), denatured type I collagen (Col ID) and denatured type II collagen (Col IID) coating on IL-6 production at Day 7, GAG content after 28 days of culture, cumulative GAG release during 28 days of culture and DNA content after 28 days of culture. Results are displayed as mean ± SD.

Tsuchida et al. Arthritis Research & Therapy 2012 14:R262   doi:10.1186/ar4107

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