Table 3

Circulating levels of tenascin-C (TNC) do not correlate with any traditional biomarkers of disease in rheumatoid arthritis (RA)

Cohort

Biomarker

Correlation with TNC at baseline?

Cohort A

CRP

No

Anti-CCP

No

ESR

No

Markers of bone and cartilage metabolism: COMP, CPII, C2C, PIIINP, hyluronan

No

Clinical score: TJC, SJC

No

Disease activity: DAS28

No

Cohort B

CRP

No

Clinical score: TJC, SJC

No

Disease activity: DAS28

No

Cohort C

CRP

No

Anti-CCP

No

Cohort D

N/A

N/A

TNC levels at baseline (entry into trial) in four separate cohorts of RA patients were analysed by ELISA. CRP, C-reactive protein; anti-CCP, anti-cyclic citrullinated peptide antibody; COMP, cartilage oligomeric matrix protein; CPII, type II pro collagen; C2C, marker of type II collagen cleavage; ESR, erythrocyte sedimentation rate; PIIINP, procollagen III N-terminal propeptide; TJC, tender joint count; SJC, swollen joint count; DAS28, disease activity score 28; N/A, data not available.

Page et al. Arthritis Research & Therapy 2012 14:R260   doi:10.1186/ar4105