Table 2

Circulating levels of tenascin-C (TNC) are raised in a number of inflammatory conditions

Sample

Mean TNC

(ng/ml)

Number of samples

P-value

(compared to N)

Patients with abnormal TNC, %


Normal healthy subjects (N)

20.7

(95% CI = 33)

19

Rheumatoid arthritis (RA)

118.2

40

< 0.0001

82.5

Systemic lupus erythmatosus (SLE)

77.8

24

< 0.0001

83.3

Sjogren's syndrome (SS)

16.7

24

0.3489

8.3

Idiopathic inflammatory myositis (IIM)

69.8

25

0.0008

64.0

Psoriatic arthritis (PSA)

64.7

6

0.0026

100.0

Ankylosing spondylitis (AS)

53.8

13

0.0006

76.9


Blood was taken from normal healthy controls (N) and patients with RA, SLE, SS, IIM, PSA and AS, and TNC levels were determined in serum by ELISA. The 95% confidence interval (CI) of TNC levels in normal healthy subjects was determined to be 33 ng/ml. The P-value was determined by Student's t-test.

Page et al. Arthritis Research & Therapy 2012 14:R260   doi:10.1186/ar4105

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