Levels of circulating tenascin-C (TNC) show a positive correlation with ultrasound-determined erosion scores prior to anti-tumour necrosis factor (TNF) therapy. (A) Levels of TNC in baseline serum samples from early rheumatoid arthritis (RA) patients (n = 24) in cohort A were determined by ELISA and compared with erosion scores at baseline as determined by high frequency ultrasonography of 10 MCP joints. Significance was determined using spearman rank correlation analysis. (B) Patients with abnormal serum levels of TNC (> 33 ng/ml) (n = 21) show higher ultrasound-determined erosion scores at baseline than patients with normal (≤ 33 ng/ml) TNC (n = 3); * P < 0.05 (t-test with Welch's correction).
Page et al. Arthritis Research & Therapy 2012 14:R260 doi:10.1186/ar4105