Table 4

Generalised estimating equations testing the effect of time on various measurements.

CRPa

ESRa

DAS28

SEVRa

MBPa

AIx


Significance of change over time

P value

< 0.001

0.004

< 0.001

0.30

0.002

< 0.001

Baseline

Meanb

8.7 (5.7 to 13.2)

16.8 (11.3 to 25.0)

4.3 (0.17)

153.3 (142.1 to 165.5)

98.9 (95.2 to 102.8)

31.9 (1.56)

2 weeks

Meanb

4.2 (2.8 to 6.4)

10.8 (7.4 to 15.9)

2.8 (0.26)

154.8 (144.9 to 165.3)

94.4 (90.2 to 98.8)

30.2 (1.74)

P valuec

< 0.001

< 0.001

< 0.001

0.69

0.010

0.11

3 months

Meanb

5.5 (3.7 to 8.3)

11.4 (6.9 to 18.9)

2.8 (0.27)

160.4 (149.6 to 172.0)

92.9 (88.0 to 98.1)

32.3 (1.98)

P valuec

< 0.001

0.05

< 0.001

0.14

0.003

0.75

1 year

Meanb

2.8 (1.6 to 5.1)

11.9 (7.9 to 17.7)

2.6 (0.29)

154.1 (140.5 to 169.1)

92.7 (87.3 to 98.5)

29.6 (2.15)

P valuec

< 0.001

0.33

< 0.001

0.85

0.002

0.13


AIx, augmentation index; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; DAS28, Disease Activity Score in 28 joints; MBP, mean blood pressure; SEVR, subendocardial viability ratio. From a generalised estimating equation, with unstructured correlation structure. aLog10-transformed prior to analysis. bData displayed as geometric mean (95% confidence interval) or mean (standard error) as applicable. cVersus baseline. Bold data represent statistically significant results.

Sandoo et al. Arthritis Research & Therapy 2012 14:R258   doi:10.1186/ar4103

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